In Ancient Rome , fellatio was considered profoundly taboo.  Sexual acts were generally seen through the prism of submission and control. This is apparent in the two Latin words for the act: irrumare (to penetrate orally), and fellare (to be penetrated orally). Under this system, it was considered to be abhorrent for a male to perform fellatio, since that would mean that he was penetrated (controlled), whereas receiving fellatio from a woman or another man of lower social status (such as a slave or debtor) was not humiliating. The Romans regarded oral sex as being far more shameful than, for example, anal sex – known practitioners were supposed to have foul breath and were often unwelcome as guests at a dinner table. 
A 2-year carcinogenicity study in mice at doses of 50, 150, and 450 mg/kg/day exemestane (gavage), resulted in an increased incidence of hepatocellular adenomas and/or carcinomas in both genders at the high dose level. Plasma AUC (0–24hr) at the high dose were 2575 ± 386 and 5667 ± 1833 /mL in males and females (approx. 34 and 75 fold the AUC in postmenopausal patients at the recommended clinical dose). An increased incidence of renal tubular adenomas was observed in male mice at the high dose of 450 mg/kg/day. Since the doses tested in mice did not achieve an MTD, neoplastic findings in organs other than liver and kidneys remain unknown.