In genetics applications, the weights are selected according to the suspected mode of inheritance . For example, in order to test whether allele a is dominant over allele A, the choice t = (1, 1, 0) is locally optimal. To test whether allele a is recessive to allele A, the optimal choice is t = (0, 1, 1). To test whether alleles a and A are codominant , the choice t = (0, 1, 2) is locally optimal. For complex diseases , the underlying genetic model is often unknown. In genome-wide association studies , the additive (or codominant) version of the test is often used.
Pricewise, our 2015 Mustang GT Premium tester’s $46,380 sticker represents what would happen if you rolled into your local Ford dealer and ticked every option box. Some of the more notable options include the new-for-2015 Adaptive Cruise Control with Collision Mitigation package, which retails for $1195, and the imaginatively named Rapid Spec Equipment Group 401A, which includes blind spot warning with rear cross-traffic alerts and a premium audio system, for $1795. If it were our money, we’d skip just about every option, instead going for the $1595 Recaro seats, and the GT Performance Package, which is a bargain at $2495 given it includes six-piston Brembo front brakes, different chassis and stability control tuning, a Torsen rear differential with , and web spoke wheels. We can live without some of the luxury and tech goodies, but those performance options aren’t to be missed.