Test propionate smell

The N–H center has a p K a of 21 in DMSO , so that very strong bases such as sodium hydride or n -butyl lithium and water-free conditions are required for complete deprotonation . The resulting organometalic derivatives can react in two ways. The more ionic salts such as the sodium or potassium compounds tend to react with electrophiles at nitrogen-1, whereas the more covalent magnesium compounds ( indole Grignard reagents ) and (especially) zinc complexes tend to react at carbon 3 (see figure below). In analogous fashion, polar aprotic solvents such as DMF and DMSO tend to favour attack at the nitrogen, whereas nonpolar solvents such as toluene favour C3 attack. [22]

Test propionate smell

test propionate smell


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