Androgens stimulate protein synthesis in muscle, and they usually do not affect the overall synthesis in the organism. Androgens stimulate the production of red blood cells by synthesis and secretion stimulation of erythropoietin, direct stimulation of hematopoiesis in bone, marrow stimulation and inclusion of iron ions in the red blood cells. Although the use of androgens causes a significant increase in hematocrit and hemoglobin levels. At the same time in healthy men, when testosterone enanthate is applied in amounts of 200 mg per week, during 16 weeks cycle, the significant increase in the number of red blood cells and the increase in the hematocrit and hemoglobin were observed.
40 mcg inhaled twice daily, approximately 12 hours apart, is the recommended starting dose. For patients who do not respond adequately to 40 mcg after 2 weeks of therapy, increasing the dosage to 80 mcg twice daily may provide additional asthma control. The maximum recommended dosage is 80 mcg twice daily. The starting dosage is based on the severity of asthma, including consideration of the patients’ current control of asthma symptoms and risk of future exacerbation. Improvement in asthma symptoms can occur within 24 hours of the beginning of treatment and should be expected within the first or second week, but maximum benefit should not be expected until 3 to 4 weeks of therapy. Improvement in pulmonary function is usually apparent within 1 to 4 weeks after the start of therapy. The National Asthma Education and Prevention Program Expert Panel defines low dose therapy as 80 to 160 mcg/day, medium dose as 161 to 320 mcg/day, and high dose therapy as more than 320 mcg/day for children ages 5 to 11 years. The Global Initiative for Asthma (GINA) guidelines define low dose therapy as 100 mcg/day in this age group. Titrate to the lowest effective dose once asthma stability is achieved.