In the dance music world, DJs cut new or otherwise special tracks on acetates, in order to test crowd response and find potential hits. This practice started as early as in the 1960s in Jamaica, between soundsystems , as a way of competing and drawing bigger crowds. These discs are known as dubplates . But the word dubplate can interchangeably mean an actual disc or just the music/recording, which can be on any other medium (. CD). Dubplates were used by reggae soundsystems worldwide, and later adopted by producers of various dance music genres, most notably drum and bass and dubstep . Trading dubplates between different DJs is an important part of DJ culture. Actual acetate dubplates are declining in popularity, and being increasingly replaced by CDs and vinyl emulation software because of weight, durability and overall cost.
In fertility studies in rats, reduced organ weights of the reproductive system, sperm counts, sperm motility , altered sperm morphology and decreased fertility were observed in males dosed for 4 weeks at ≥ 30 mg/kg/day. Mating of untreated females with males that received 30 mg/kg/day abiraterone acetate resulted in a reduced number of corpora lutea, implantations and live embryos and an increased incidence of pre- implantation loss. Effects on male rats were reversible after 16 weeks from the last abiraterone acetate administration. Female rats dosed for 2 weeks until day 7 of pregnancy at ≥ 30 mg/kg/day had an increased incidence of irregular or extended estrous cycles and pre-implantation loss (300 mg/kg/day). There were no differences in mating, fertility, and litter parameters in female rats that received abiraterone acetate. Effects on female rats were reversible after 4 weeks from the last abiraterone acetate administration. The dose of 30 mg/kg/day in rats is approximately times the recommended dose of 1,000 mg/day based on body surface area .