Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes. 
On 31 January 2012 it was announced that Manhoef had signed with ONE Fighting Championship and would be fighting Renato Sobral in the main event at ONE Fighting Championship 3 .  However, Sobral pulled out of the fight and Manhoef faced Yoshiyuki Nakanishi. The fight ended in a No Contest due to an accidental injury to Manhoef's leg in round 1. Manhoef scored a knockout victory on 6 October 2012 against Ryo Kawamura, followed by a quick knockout of Dennis Kang on 31 December 2012. Melvin is now on a three fight win streak in mma and has gone 4-0 on New Year's Eve.
At this point, Dr. Doom had been usurped from his position as ruler of Latveria, a mantle he desperately wanted to reclaim. Doom devises a scheme in which he would enlist the Hulk as the first member of an army that would eventually wrestle control of the control back to Doom. Doom approaches the Hulk, but the Hulk isn’t having it and goes on the offensive. Doom knows that he can’t possibly beat the Hulk in a physical contest, so he utilizes his “neuro-ray” in order to take control of the Hulk’s movements, incapacitating him. The Hulk recognizes that his brute strength pales in comparison to Doom’s technological superiority, so he agrees to listen to Doom’s proposition.