In genetics applications, the weights are selected according to the suspected mode of inheritance . For example, in order to test whether allele a is dominant over allele A, the choice t = (1, 1, 0) is locally optimal. To test whether allele a is recessive to allele A, the optimal choice is t = (0, 1, 1). To test whether alleles a and A are codominant , the choice t = (0, 1, 2) is locally optimal. For complex diseases , the underlying genetic model is often unknown. In genome-wide association studies , the additive (or codominant) version of the test is often used.
One of the biggest criticisms is the AWD select knob, which takes more effort than it should to switch modes, and it’s hard to figure out which one was selected because the symbols are hard to decipher and nothing in the instrument cluster shows which mode you’re in. The only way to tell AWD is on without looking down at the switch is to go to the off-road menu. We envision drivers getting stuck in the snow their first winter because they forgot to switch into AWD. In an era where computers can detect your terrain and engage or disengage AWD as needed, it is hard to understand why GMC made this so difficult for the user.